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CBGV: The Cannabinoid That Increases the Effects of Medical Marijuana

Research suggests CBGV playsa key role in helping CBD attach to the body’s receptors once ingested, increasing the overall benefits of medicinal marijuana.

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CBGV
PHOTO | Jesse Barney
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The cannabis herb produces literally hundreds of different chemicals, many of which have been proven to offer significant health benefits to humans, including the ability to shrink cancerous tumors, reduce pain, and even reduce or eliminate the seizures associated with conditions such as epilepsy.

113 cannabinoids have been identified in cannabis since 1964 when Dr. Raphael Mechoulam in Israel first discovered what has proven to be a set of very medicinal and beneficial molecules in the lives of humans.

When Mechoulam discovered cannabinoids such as tetrahydrocannabinol (THC), the chemical responsible for most of the psychoactive effect and euphoria delivered by cannabis, he also uncovered the hidden mechanism by which these molecules interact with the human body, called the Endocannabinoid System (ECS). To the amazement of many cannabis consumers, all mammals feature an ECS, meaning that cannabinoids have efficacy for common pets, such as cats, dogs, and even hamsters.

The ECS modulates and regulates a wide variety of physiological and cognitive processes including appetite, fertility, pain-sensation, pregnancy, memory, and mood. The theory of endocannabinoid deficiency asserts that modern life, including poor diet, lack of exercise, environmental stressors, and pollution lead to problems in the ECS that result in major diseases such as cancer, fibromyalgia, multiple sclerosis, epilepsy, Crohn’s disease, depression, and social anxiety.

The Details on CBGV

One of the most beneficial medicinal cannabinoids offered by the cannabis herb is cannabigerivarin (CBGV), a derivative of cannabigerol (CBG), a molecule that has been described as the “mother of all cannabinoids” due to its role as the molecular source of all other cannabinoids — including THC and cannabidiol (CBD).

Like most cannabinoids, CBGV produces no psychoactive effects when ingested or inhaled. Researchers theorize that it may boost the ability of the cellular receptors in the ECS to more readily bind with THC molecules. Some researchers believe that CBGV also boosts CBD metabolism within the body, making CBD more potent when paired with this cannabinoid.

CBGV has been found to display analgesic (painkilling) and anti-inflammatory properties, making it effective for conditions such as fibromyalgia and arthritis. Although many cannabinoids have been found to improve the quality of skin or combat diseases of the epidermis, CBGV features the relatively unique characteristic of improving and sometimes cure dry-skin conditions.

Like other cannabinoids, CBGV provides great promise in cancer treatment, especially for those undergoing chemotherapy and radiation. Clinical research has observed CBGV to be cytostatic in leukemic cells, meaning that it inhibits the growth and division of these cancer cells.

The Research

A 2013 research study conducted in London, England and entitled “Non-hallucinogenic Cannabinoids are Effective Anti-cancer Drugs” that was published in the journal Anticancer Research demonstrated the cancer-fighting properties (in this case, for leukemia) of six cannabinoids: Two forms of cannabidiol (CBD), two forms of CBG, and two forms of CBGV.

Concluded the study’s researchers, “These agents are able to interfere with the development of cancerous cells, stopping them in their tracks and preventing them from growing. In some cases, by using specific dosage patterns, they can destroy cancer cells on their own. Significantly, these compounds are inexpensive to produce could result in much more cost effective anti-cancer drugs in future.”

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Peach Oz: This Sweet And Juicy Cultivar Will Stimulate Your Creativity

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PEACH FUZZ | PHOTO: WONDERBRETT

If you’re looking for a premium cultivar with legendary genetics and a euphoric high, look no further than Peach Oz, the latest addition to Wonderbrett’s stellar strain menu.

A cross of Peach Rings with OZ Kush and a descendent of Zkittlez, the sweet, stimulating citrus taste profile of Peach Oz will get your creative juices flowing.

While the cultivar may be new to the public, according to Wonderbrett Co-Founder and famed Breeder Brett Feldman, it’s five-years-old in the world of genetics.

“There’s only a small handful of heady smokers who follow these things,” says Feldman. “I wanted to bring it to the masses to share the experience with everybody. That’s where my passion comes from with this strain. Similar to an amazing dish at a restaurant, you want to share it with your friends.”

Grown in small-batches at scale from the company’s state-of-the-art Long Beach cultivation facility, the strain was first created by Dying Breed Seeds, then perfected by Cannabis By Corey, before making its way to Feldman.

Wonderbrett’s grow room | PHOTO: Courtesy Wonderbrett

Bursting with flavors and aromas that bring to mind the sweet ocean breeze and fragrant fruit orchards of the California sunshine state, Peach OZ’s four dominant terpenes: Caryophyllene, Linalool, Limonene and Humulene, create a distinct sweet taste of ripe peaches, citrus candy and cream.  

“When any strain has that unique, recognizable consistency in its flavor, whether that be peach, lemon or orange, that’s what myself and other breeders appreciate most and look for when bringing a genetic like this to market. It’s mind-blowing what Peach OZ can do that, translating a fruit flavor to a smoking experience,” explained Feldman.

Peach OZ is available at select dispensary and at Wonderbrett’s flagship dispensary in L.A.

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Pink Lemonade: This Sparkling Strain Is Both Pretty & Potent

The frosted pink buds of Pink Lemonade might dazzle the beholder with glittering layer of golden trichomes, but this gorgeous flower isn’t all looks.

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Pink Lemonade
PHOTO | Anna Wilcox

Dusted with a glittering layer of golden trichomes, the Pink Lemonade strain is endowed with a mystical appearance that embodies everything curious, attractive, and intriguing about cannabis flowers. Tightly bound calyxes dazzle with a bouquet of pink, violet, and sage coloration.

Cracking open one of these flowers emits a comfortable herbal aroma. A burst of crispness teases the nose, somewhat akin to the tart fizz in a carbonated cherry drink. This dessert-like aroma nicely compliments a definite happy hour high. Calm, relaxed, and downright chill, Pink Lemonade is a true afternoon delight.

The Pink Lemonade High

Put on some chill beats and pour yourself a nice drink. This plant is smooth, easy, and well-rounded. If inhaling Pink Lemonade feels like the first meaningful breath you’ve taken all day, you might be pleasantly surprised as a subtle relaxation works its way along the limbs and through the muscles.

There’s no doubt about it–this plant is a go-to strain for mellowing out. While often described as thoughtful and creative, the herb is better suited to leisure activities than it is serious concentration.

While solo consumers may enjoy putting on some Netflix after a little of this plant, it’s peaceful and contented nature is ideal for social gatherings. Spending time with friends may always be fun, but it’s easy to sit back enjoy a pleasant conversation after a few tastes of Pink Lemonade.

It’s worth mentioning, however, that cannabis affects everyone differently. The herb tends to be a mood enhancer rather than an instant remedy for happiness. If you are in an easygoing and relaxed environment, expect even more mellow after enjoying a little bud. If you’ve been having a bad day, strains like Pink Lemonade may provide relief by softening negative emotions and making them more tolerable.

Pink Lemonade Strain Background

Today’s cannabis market is truly a craft one. To say that the lack of federal recognition of the herb is problematic is an understatement. However, one benefit of state-by-state legalization is the development of truly local, expertly crafted products.

Pink Lemonade is a superb example of such a flower. There are many renditions of Pink Lemonade out there, yet the particular version pictured is a cross between two contemporary hybrids, Lemon Cheesecake and Huckleberry Soda.

Each parent strain is exceptional in its own right. Lemon Cheesecake is a sativa-dominant flower with a sour cream aroma and substantial THC production. Huckleberry Soda is a craft hybrid from Annunkanki Genetics, an intriguing cross between two hybrids, Black Cherry Soda and Huckleberry Hound.

Pink Lemonade Strain Benefits

As a craft flower, Pink Lemonade was arguably bred more for enjoyment than serious medical potential. It’s frosted pink buds dazzle the beholder, showcasing the fact that this plant is truly a treat. However, this gorgeous flower isn’t all looks.

The flower produces upwards of 25 percent THC. This means that the plant may be useful to those who benefit from high-THC therapies. Those interested in making a full-extract oil, hash, or other forms of concentrates may also enjoy experimenting with this sugary herb.

This plant is not too energizing nor is it overly sedative. However, those hoping for a little extra help falling asleep at night may find the flower helpful. The relaxed flower may also be beneficial for anxious individuals in search of a social lubricant.

However, the high-THC content in Pink Lemonade can inspire the opposite effect in some people. Bottom line: if you are prone to social anxiety or often respond poorly to THC, this potent flower is likely not the best choice.

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Wizard Stones: The Magic of Making Cannabis Diamonds

Aaron Palmer and Graham Jennings, founders of Oleum Extracts in Washington State, talk about Wizard Stones, their THCA isolate product.

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Wizard Stones
PHOTO | Oleum Extracts

Heat, pressure, and time. The three components required to form a diamond from carbon. But what about diamonds made from cannabis? The founders of Oleum Extracts, Aaron Palmer and Graham Jennings both agree that a good cannabis diamond aka Wizard Stones ultimately comes down to the flavor provided by its terpene fraction.

‘Diamonds’ is a slang term for the crystal formations of the cannabinoid THCA. The molecule’s lattice structure builds upon itself naturally as individual molecules clump together creating the faceted formations that resemble diamond or quartz.

When most people talk about cannabis diamonds, they’re talking about THCA structures that form in their own terpene sauce. So, it’s a little different technique than other isolation methods.

While their chemical composition is the same, the process to make them is slightly different than the traditional diamonds mined from a raw extract. Instead, they use a specially formulated solvent mix to create a solution with a composition that encourages crystallization.

Due to Washington state’s regulations, Oleum is limited in the chemical solvents they can use. So that blend is the crucial variable to isolating THCA into their Wizard Stones product.

Growing cannabis diamonds within their original terpene fraction comes down to creating an environment with the right amounts of pressure and heat to encourage crystal growth.

Within the raw extract, the terpene and cannabinoid compounds are homogenized together, but as they settle and separate the mixture “crashes” — which is the start of crystallization.

Palmer explains that this process “helps to create a seed because if there’s nothing for the THCA molecules to grab onto then they have a harder time starting the diamond formation.”

There are a few ways extractors seed a solution to start diamond growth, but Oleum prefers to use freezing temperatures to solidify and then thaw their extract, helping to create small groupings of THCA for other molecules to stack off.

Another common seeding technique is to drop a previously grown crystal into the extracted mixture of cannabis compounds, giving the THCA something to grow off.

This technique is especially useful when filming a time-lapse of the crystal growth because it gives the camera a focal point knowing where the formation will grow from.

Creating Wizard Stones

The above timelapse video was photographed over a four day period by Dankshire. We can see diamonds begin to form almost immediately. However, the crystallization process can take a month if not longer to complete once a raw extract is jarred and waiting to crash.

Oleum utilizes custom-built isolation vessels for their production diamond runs but admits that the jar tech allows more visibility into the process.

Jennings points out, “You see the jars, we even do the jar stuff a lot. It’s more popular… and people know what it is compared to a large isolation vessel that no one can see into it but you know it’s growing 2,000 grams of crystals.”

Each batch can present a different ratio of diamonds to sauce and it seems like everyone wants a little different combination. “We just give ‘em what it makes,” Jennings said.

That’s the beauty of isolated products like cannabis diamonds and sauce; you can mix your own cocktail of cannabis compounds and really dial in the flavors and feelings that you’re after.

Wizard Stones grown in their own sauce create a potent, refined, and pronounce expression of the strain they are extracted from.

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