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THCV: The Cannabinoid That Can Help With Weight Loss

What sets THCV apart from the other cannabinoids is it has the ability to suppress appetite, as studies are demonstrating.

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THCV
PHOTO | Gracie Malley
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More than 113 cannabinoids have been discovered in the cannabis plant, including tetrahydrocannabivarin, or THCV. An obvious molecular cousin to the infamous euphoric tetrahydrocannabinol (THC), THCV offers distinct characteristics in the world of cannabinoids.

According to Raphael Mechoulam, the Israeli researcher who discovered THC in 1964, “Most of the cannabinoids in cannabis have not been fully evaluated for their pharmacological activity. Tetrahydrocannabivarin is a potent antagonist of anandamide, a major endogenous cannabinoid. It seems possible that many of the non‐psychoactive constituents of this plant will be of biological interest.”

The Details on THCV

Probably the most distinct — and distinctly marketable — aspect of THCV is its ability to suppress appetite. This characteristic of this molecule is the opposite of THC, which has a reputation for enhancing appetite to create what is sometimes dubbed “the munchies.” This cannabinoid should be avoided by those suffering from anorexia.  

The medical community finds obvious interest in the appetite suppressing qualities of molecules such as THCV. The efficacy of natural and non-addictive products, lacking the side effects of traditional pharmaceutical therapies, is of obvious benefit to consumers suffering from conditions like obesity and Type 2 diabetes.

THCV regulates blood sugar levels and reduces insulin resistance. It is believed to be helpful for osteoporosis and other bone-related conditions. For the same reasons that it is helpful for Alzheimer’s disease, this special cannabinoid shows promise for alleviating the symptoms of and delaying the neurodegeneration associated with Parkinson’s disease. THCV may also prevent and relieve panic attacks in PTSD patients.

Cannabis strains rich in THCV include Doug’s Varin, Durban Poison, Jack the Ripper, Pineapple Purps, Power Plant, Red Congolese, Skunk #1, and Willie Nelson. It is more common in sativa varieties of the herb.

The Research

Research into the medicinal efficacy of cannabinoids like THCV is increasing, although thwarted in the United States by the Schedule 1 status of cannabis. A number of studies have revealed the neuroprotective and blood sugar regulation qualities of THCV, spotlighting its efficacy for senior patients with diseases such as Alzheimer’s disease.

A 2011 study entitled “Symptom‐relieving and Neuroprotective Effects of the Phytocannabinoid Δ9‐THCV in Animal Models of Parkinson’s Disease” published in the British Journal of Pharmacology concluded that THCV can be a beneficial therapy for patients with diseases involving neurodegeneration, including Parkinson’s disease.

The study’s researchers concluded, “Given its antioxidant properties and its ability to activate CB2, but to block CB1, receptors, THCV has a promising pharmacological profile for delaying disease progression in Parkinson’s disease and also for ameliorating Parkinsonian symptoms.”

A review article published in 2012 in the journal Frontiers in Endocrinology entitled “Role of Cannabinoids in the Regulation of Bone Remodeling” demonstrated that the human endocannabinoid system—which features CB1 and CB2 receptors that bind with cannabinoids like THC and THCV—is present in not only the brain, central nervous system, and immune system, but also throughout the skeletal system.

Concluded the study, “The endocannabinoid system plays a key role in regulating a variety of physiological processes, such as appetite control, energy balance, pain perception, and immune responses. Recent studies have implicated the endocannabinoid system in the regulation of bone cell activity and bone remodeling.”

Cannabis

New York Opens Cannabis Nursery Applications November 5

New York’s first nursery application window opens November 5, with an initial review of 50 applications for businesses supplying seeds and young plants.

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Young cannabis plant in a pot with a Blueberry Cupcake label

New York is opening a new door for the businesses behind the plants. Its first adult-use cannabis nursery application window begins November 5, 2026, creating a dedicated licensing route for suppliers of seeds, clones and immature plants.

The immediate opportunity is for businesses supplying licensed growers. A nursery license alone will not allow direct sales to consumers or home growers, according to the Office of Cannabis Management’s guidance.

A small first round, with more to follow

The Cannabis Control Board approved the window on October 1. OCM will consider the first 50 applications received, reviewing them in submission order once that target is reached. Applications beyond the initial 50 will not be considered in this round, and those applicants’ fees will be returned.

That number describes the opening round, rather than a permanent statewide ceiling. In an October 21 analysis, Vicente LLP’s Bridgette Nikisher and Brandon Kurtzman explain that the staged approach is intended to manage the rollout. Additional application windows are planned.

What prospective nursery operators should prepare

OCM lists a $1,000 application fee, with separate license fees based on outdoor, mixed-light or indoor cultivation. Qualified social and economic equity applicants can receive a 50% reduction in application and license fees.

Vicente’s application overview highlights several preparations: a Nursery Grower Certificate of Registration, proof of control over the proposed location, a labor peace agreement and business ownership information. Applications will go through New York Business Express.

For cannabis enthusiasts, the distinction matters: this is an upstream supply development, not the opening of a new home-grow shop. It puts the focus on how licensed growers obtain their starting material—the part of a cultivation story that begins before the flower reaches a dispensary shelf.

Related reading: How California’s growing footprint shapes its harvest.

A young cannabis plant. Illustrative stock photograph; not a New York licensed nursery. Photo: Colin redwood / Unsplash.

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Colorado Cannabis Safety Audit Calls for Stronger Oversight

A Colorado audit calls for improvements to cannabis oversight, while finding no evidence supporting claims of widespread product safety problems.

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Blue-gloved hand holding a glass beaker of clear liquid in a laboratory

A new Colorado audit raises a question that goes beyond whether cannabis has passed a laboratory test: how well can the state independently check that the system is working?

The Marijuana Consumer Safety performance audit, released October 19, identifies weaknesses in regulatory oversight and testing support. It also makes a crucial distinction: auditors found no evidence supporting claims of widespread health and safety problems in regulated marijuana products.

Where the audit sees gaps

The report describes limits in state reference laboratory capacity, inconsistent monitoring and weaknesses in how potential problems are investigated and communicated. These findings concern the safeguards around the market; they do not amount to a finding that every product is unsafe.

One example is independent testing capacity. As of May 15, 2026, the state reference laboratory could not test for pesticides, residual solvents or mycotoxins—tests required for marijuana products sold in Colorado. That limitation concerns the state laboratory’s ability to support oversight, not the absence of those requirements for commercial products.

Why independent checks matter

For readers comparing flower, concentrates or edibles, a test result and the system supervising that result answer related but different questions. Product testing examines a sample. Oversight asks whether the sampling, methods and follow-up can be trusted across the market.

The audit made 14 recommendations, and the agencies agreed with all 14. Agreement marks the beginning of the response; it does not establish that the recommended improvements are already complete.

The useful takeaway is to read the findings at their actual scope. This is a call to strengthen Colorado’s safety framework, not a blanket warning against every regulated product or a product-specific recall.

Related reading: Why independent cannabis testing matters.

Laboratory equipment in use. Illustrative stock photograph; not a Colorado cannabis testing facility. Photo: RephiLe water / Unsplash.

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Kentucky’s Medical Cannabis Network Reaches 26 Open Dispensaries

Kentucky now lists 26 operating medical cannabis dispensaries, as Governor Andy Beshear reports 46 of 80 approved businesses are up and running.

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Glass jars of dried cannabis flower arranged on a retail counter

Kentucky’s medical cannabis market is becoming easier to find on a map. The state’s October 16 directory lists 26 operating dispensaries, while Governor Andy Beshear’s latest update puts the wider business rollout past its halfway point.

Beshear said on October 21 that 46 of 80 approved cannabis businesses were operating, according to Tom Angell’s reporting for Marijuana Moment. That total includes 13 cultivators, two safety compliance facilities, five processors and 26 dispensaries.

Open doors matter more than licenses alone

The figures describe a supply chain taking shape, rather than 46 places where patients can shop. Cultivators, processors and testing facilities perform different roles from dispensaries; combining them into one number can make access sound broader than the retail footprint alone.

Kentucky’s official dispensary directory separates operating locations from the larger set of licensed businesses. Its October 16 update includes Sunnyside Prestonsburg, open since October 13, and a Lexington location operated by DHK KY LLC, open since October 16.

The directory warns that some licensed dispensaries are not yet operating and that locations can change. For someone planning a visit, the operational list is a more useful starting point than a license announcement. Checking the retailer’s current hours before traveling is a sensible next step.

A growing network, with work still ahead

Beshear also cited more than 29,000 people approved for medical cannabis cards and more than 500 registered practitioners, Marijuana Moment reported. Those are the governor’s figures, not an independent measure of patient satisfaction or product availability.

Kentucky’s medical cannabis program took legal effect January 1, 2025. Its website provides practitioner searches, card application information and patient education sessions. As the network expands, those practical resources help turn a statewide milestone into a clearer path for individual patients.

Cannabis flower displayed in glass jars. Illustrative stock photograph; not a Kentucky dispensary. Photo: Cova Software / Unsplash.

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