Cannabinoid-Based Medicine: How and Why Is Cannabis Medicine?
Despite a more than 5,000 year history of safe, medicinal cannabis use, science is just starting to understand cannabinoid-based medicine.
Weed. Drug. Banned substance. Medicine. The cannabis plant goes by many monikers.
Recent history has vilified what ancient history commended. Now, as more and more people around the world gain access to cannabis, it’s become better known for its therapeutic properties.
Millions of American use cannabis every day to help treat symptoms of conditions that range from epilepsy to PTSD, cancer, to nausea. Patients most commonly use it to treat chronic pain, and symptoms of Multiple Sclerosis (MS), glaucoma, HIV/AIDS, arthritis, insomnia and inflammatory bowel disease (IBD), to name a few.
But, what makes marijuana medicinal? The (short) answer is cannabinoids.
Cannabinoids – or phytocannabinoids – are the naturally occurring group of active chemical compounds found in the cannabis plant. There are over 100 different cannabinoids; some of the most well known are Tetrahydrocannabinol (THC) and Cannabidiol (CBD).
Both CBD and THC are the main chemicals used in cannabis-based medicine. But, each cannabinoid has a different effect on the body (not all are known). THC is known for the psychoactive or high effect it induces. CBD, on the other hand, is non-psychoactive.
In fact, most cannabinoids do not have psychoactive effects. Each is thought to influence the body in different ways. Research suggests that some cannabinoids like cannabinol (CBN) treat symptoms associated with inflammation or pain, while others (THC, CBD) have neuroprotective qualities.
Individual cannabinoids can be isolated and extracted, or synthesized. The concept is used in the development of synthetic cannabinoid-based medicines, such as Marinol. Isolating compounds allows humans to reap the benefits of particular cannabinoids. However, it’s believed that these chemicals work most effectively when used together, known as the entourage effect.
Understanding Cannabinoid-Based Medicine
So, how do these compounds actually affect our bodies?
When consumed, cannabinoids activate or trigger receptors. Those receptors are found throughout our bodies – e.g. organs, nervous system, brain, connective tissue, immune cells, glands, etc. – and help make up the endocannabinoid system (ECS), a biochemical communication system within our bodies.
To oversimplify: If cannabinoids were keys, receptors are the locks. Once unlocked, receptors send messages to cells.
Researchers have so far found two types of receptors: CB1 and CB2. Each has a different role to play, and each responds differently to various cannabinoids. (There are other receptors thought to engage with cannabinoids, but these are the main ones).
The highest concentration of CB1 receptors is found in the brain and in the spinal cord. CB2 receptors are predominantly found in immune cells and GI tract.
Interestingly, high densities of CB1 receptors are found in the hippocampus, cerebellum and other regions in the brain responsible for regulating appetite, mood, memory, etc. They’re also found in nerve endings.
Due to the concentration of CB2 receptors in immune cells, they are thought to help the body respond to disease.
These receptors are also activated by our body’s own cannabinoids aka endocannabinoids. One such endocannabinoid is anandamide or the bliss molecule. It’s a neurotransmitter that’s produced on demand by the body when it’s needed. Anandamide is fragile, like all other neurotransmitters. It’s known to regulate mood, appetite, pain, cell regulation, and even reproduction.
A scientific study published last year was the latest to focus the research community on the potential of the GPR55 receptor, which is now known to be the third identified receptor.
Unlike most other cannabinoids, research suggests that CBD does not directly bind to the receptors mentioned above. Instead, it’s believed to help build up our body’s supply of anandamide. It does this by inhibiting the FAAH enzymes that deplete levels of anandamide, and other endocannabinoids.
Despite a more than 5,000 year history of safe, medicinal cannabis use, science is just starting to understand cannabinoids, cannabinoid-based medicine and the ECS. What we do know about this complex system is that it has a vital role to play in the human body.
Cannabis Classification System Announced for 2022 Emerald Cup Awards
One of the factors that make the Emerald Cup so important to California’s cannabis market is its continued strive for excellence and innovation. For the 2022 awards, the judging process is undergoing a transformation and with it comes a new cannabis classification system that will classify entries based on terpenes, flavour, and effects for anybody — from customers to budtenders, dispensaries, judges, and cultivators.
Cannabis Is More Than Just THC
The days of just searching out the highest THC totals are rapidly receding as research has now proven that terpenes are at the base of the entourage effect that customers desire are rapidly fading.
Terpenes, on the other hand, have mostly added to the consumer confusion already caused by overly broad Indica/Sativa/Hybrid terminology, whimsical strain names, irrelevant THC/CBD percentages, and other ambiguous factors that make selecting the best or correct strain a less-than-satisfying ordeal for even the most experienced cannabis connoisseurs.
The Emerald Cup competition will serve as a testbed for a new classification system for cannabis flowers. The event organisers and their testing partners at SC Labs decided to further break down the flower categories based on the chemometrics of each cultivar (better known as “chemovar” — the evolution of the term “dominant terpene”) evolving beyond last year’s flower category sorting by primary terpene content, in order to level the playing field and eliminate as much bias as possible in the blind/anonymous sampling done by Emerald Cup judges each year.
This paradigm-shifting insight sparked months of additional research and discussion, culminating in the Emerald Cup Cannabis Classification System based on PhytoFacts® powered by SC Labs.
The all-new classification system builds on last year’s approach of sorting flower entries by primary terpene content, leveraging a decade of Cannabis phytochemistry research between PhytoFacts®, developed by Napro Research in 2013, and a powerful database of over 250,000 terpene tests aggregated by SC Labs, dating back to their launch of terpene testing on Cannabis in 2013. The key class names were chosen to represent current terminology, are widely used in the business and are familiar to dispensaries and consumers. Each class is further explained using taste notes, effects, and popular strains or cultivars to promote understanding and acceptance.
The New Cannabis Classification System
The classes of the Emerald Cup Cannabis Classification Based on PhytoFacts® powered by SC Labs include:
“Jacks + Haze” Class
- Mostly ‘Sativa’-leaning varietals
- Tasting notes – Fruity, Pinesol, Haze
- Effects – Energizing, Cerebral, Artistically Inspiring
- Common Cultivars – Classic Trainwreck, Jack Herer, Durban Poison, Super Lemon Haze
- Terpenes Profile: Terpinolene, Caryophyllene, Myrcene
“Tropical + Floral” Class
- Mostly ‘Indica’-leaning varietals
- Tasting notes – Sweet, Floral, Tropical Fruit
- Effects – Calming, Soothing, Relaxing
- Common Cultivars – Super Skunk, Hawaiian, In the Pines, Dream Queen
- Terpenes Profile: Ocimene, Myrcene
“Sweets + Dreams” Class
- Mostly ‘Indica’-leaning varietals
- Tasting Notes – Fruity, Sweet, Woody, Hoppy, Herbaceous
- Effects – Relaxation, Couch Lock, Analgesic
- Common Cultivars – Blue Dream, Tangie, Forbidden fruit, Grandaddy Purple, Purple Urkel, Grape Ape, Cherry AK, God’s Gift, Purple Punch
- Terpenes Profile: Myrcene, Pinene, Caryophyllene
“OGs + Gas” Class
- True ‘Hybrid’ varietals
- Tasting Notes – Gas, Fuel, Sweet, Citrus, and Pepper
- Effect – Uplifting, Stimulating, Analgesic, Relaxation
- Common Cultivars – Classic OG Kush, ChemDawg, Sour Diesel, Gorilla Glue
- Terpenes Profile: Any combination or shifting codominance of Caryophyllene, Limonene, Myrcene
- True ‘Hybrid’ varietals
- Tasting Notes – Deserts, Doughs, Citrusy & Spicy
- Effects – Stimulating, Racy, Uplifting, Comforting
- Common Cultivars – Classic Bubba Kush, GSC, Gelatos, Cakes
- Any shift in codominance of Caryophyllene & Limonene
“Exotics” (Rare Terpene Combinations) Class
- True ‘Hybrid’ varietals
- Tasting notes – varied based on chemistry of entry
- Effect – varied based on chemistry of entry
- Common Cultivars – rarest terpene profiles entered into the Emerald Cup Competition
This game-changing development in cannabis classification levels the playing ground for the 2022 Cup as well as market competitiveness amongst brands. The system seeks to become an open-source, globally recognised grading solution for Cannabis, with six simple classes/names/descriptions. In the same way that a Chardonnay would not be tested against a Merlot in the wine business, this new system permits strains with comparable profiles to be judged against each other. This new classification system will also be used at the California State Fair Cannabis Awards in July 2022.
The 2022 Emerald Cup Awards will be presented live on stage on May 14th at the Green Street Festival in Downtown Los Angeles, California.
The Sativa Preservation Society Project Will Protect Rare Haze Genetics
Space Coyote, the totally cosmic cannabis company, has launched the Sativa Preservation Society Project — a movement that protects Haze genetics while paying homage to the custodians and cultivators who kept the seeds alive.
Celebrators of the cannabis culture’s stoner heritage, Space Coyote’s aesthetic and ethos embraces the vibes and psychedelic Seventies scene, where the creativity and community of cannabis intersect.
Co-founder and self-confessed ‘Sativa Diva’ Libby Cooper calls it the “ultimate passion project”.
“We’re truly passionate about saving these genetics that are the actual grandmothers of every modern-day sativa strains that people love — all of these desert strains, all of the fruity strains,” Cooper tells me from the Space Coyote van en route to Hall of Flowers.
Founding the Sativa Preservation Society Project
The concept of the Sativa Preservation Society Project was years in incubation as the Space Coyote team deliberated over how to bring it to life. It was important for them to give back to the community while helping to educate about the history of cannabis culture.
The stars aligned earlier this year when the team met Bam Vachher-Gnanathurai, nursery and plant breeding manager from the Posibl Project in Salina. A mutual love of the unique effects of Haze genetics made for a truly cosmic outcome.
“Bam is super passionate about sativa,” said Cooper. “When we went and met up with Bam for the very first time, he rolled a blunt from Cuban Black. It was such an amazing experience to smoke that flower.”
“The initial conversation of the Sativa Preservation Society coming to life happened during that smoke session. It was like, ‘holy shit, we could actually do this.’”
The Haze Experience
The Sativa Preservation Society Project is launching with three incredibly rare cultivars — Cuban Black Haze, Uptown Haze (also known as A5 Haze), and C5 Haze — all of which were originally cultivated in the 1980s by legendary grower Neville Schoenmaker. The flower will be available as bagged eighths and as infused prerolls.
Cooper likens the Haze experience to being “a bit like mushrooms” — colors are brighter, your smell is enhanced and your hearing is sharper.
“It’s really like a cup of coffee without any jitteriness or anxiety usually associated with sativas. This is pure energy without any sort of adverse effects,” explains Cooper. “You really feel as if your eyelids are getting peeled back — you’re awake, you’re uplifted. Basically, I smoke it and I immediately start stretching.”
“Many sativa genetics are dying out due to a number of reasons,” says Cooper. “Typically, they are more difficult to grow, have a longer curing time, and the fluffy buds are easily crushed in transit.” All of which makes sativas less cost-effective in California’s highly competitive legal market.
“This truly is the first time these original sativa strains are going to be commercially grown,” says Cooper. “It really wouldn’t have been possible, funnily enough, without this group named Posibl.”
Learn more about the Sativa Preservation Society Project in the video above. While you’re at it, find your nearest Space Coyote here.
Peach Oz: This Sweet And Juicy Cultivar Will Stimulate Your Creativity
If you’re looking for a premium cultivar with legendary genetics and a euphoric high, look no further than Peach Oz, the latest addition to Wonderbrett’s stellar strain menu.
A cross of Peach Rings with OZ Kush and a descendent of Zkittlez, the sweet, stimulating citrus taste profile of Peach Oz will get your creative juices flowing.
While the cultivar may be new to the public, according to Wonderbrett Co-Founder and famed Breeder Brett Feldman, it’s five-years-old in the world of genetics.
“There’s only a small handful of heady smokers who follow these things,” says Feldman. “I wanted to bring it to the masses to share the experience with everybody. That’s where my passion comes from with this strain. Similar to an amazing dish at a restaurant, you want to share it with your friends.”
Grown in small-batches at scale from the company’s state-of-the-art Long Beach cultivation facility, the strain was first created by Dying Breed Seeds, then perfected by Cannabis By Corey, before making its way to Feldman.
Bursting with flavors and aromas that bring to mind the sweet ocean breeze and fragrant fruit orchards of the California sunshine state, Peach OZ’s four dominant terpenes: Caryophyllene, Linalool, Limonene and Humulene, create a distinct sweet taste of ripe peaches, citrus candy and cream.
“When any strain has that unique, recognizable consistency in its flavor, whether that be peach, lemon or orange, that’s what myself and other breeders appreciate most and look for when bringing a genetic like this to market. It’s mind-blowing what Peach OZ can do that, translating a fruit flavor to a smoking experience,” explained Feldman.
Peach OZ is available at select dispensary and at Wonderbrett’s flagship dispensary in L.A.