There is a high probability that the following scene has played out at least once in your life: after passing a joint around a smoke circle, one person can’t stop laughing at the painting they insist is moving, another is proclaiming the profundities of Kenrick Lamar’s lyricism, and yet another is “resting their eyes”. While humorous to observe the panoply of personalities, this setting provides an important observation. The cannabinoids and terpenes found in different cannabis products interact with everyone’s internal biochemistry differently.
Naturally, aspects of your lifestyle like how much exercise you’ve been getting, your sleep patterns, and diet all play a role in how you’ll respond to a cannabis product on any given day. However, the most critical factor is the makeup of your endocannabinoid system — the chemicals and neurons in your brain and body that respond to cannabinoids. Your DNA holds the specific instructions for how your endocannabinoid system gets “wired up” compared to other people, permitting for individual differences in reactions to cannabis.
A Quick Introduction to DNA
DNA (deoxyribonucleic acid) is a long molecule that contains the instructions for building every single part of an organism. DNA is made up of four compounds that pair up: (A) Adenine, (T) Thymine, (C) Cytosine, and (G) Guanine. 99.5% of the base pair combinations that make up humans are identical from person to person. The .5% difference is what makes you unique. Variants are the genetic differences that make up that .5%.
You may be familiar with the term “gene”, which is simply a section of DNA that carries the codes for making and organizing specific molecules that eventually serve as the building blocks for different parts and functions of an organism. Variants at specific genes have been identified as the determinants for thousands of different traits, from whether you’ll have blue or green eyes to whether or not you’ll have muscular dystrophy. As new research is conducted on cannabis and the body, more genetic links that can predict your response to cannabis are beginning to surface.
How Your DNA Affects Your Cannabis Consumption
With genes holding the instructions for the creation of enzymes and proteins that go on to make up all the constituents of your brain and body, it is a small leap of understanding to see how variants at specific genes can affect your endocannabinoid system and, subsequently, your experience with cannabis.
An extreme example of this is Clinical Endocannabinoid Deficiency (CECD) — a genetic condition where the carrier’s body produces significantly less endogenous cannabinoids and receptors as compared to a healthy person. CECD presents an obvious linkage between DNA and cannabis use: if you carry a gene for CECD, you will require substantially more cannabis in order to achieve the same effects as someone without that gene. Other genetic links that predict your response to cannabis can be a bit more insidious.
Take the genes CYP2C9 and CYP2C19 for example; they code for an enzyme that breaks down THC and CDD respectively. Variants on these genes can make the enzymes they create up to 30% less effective. This means that consumers with those variants would be less effective in breaking down THC and CBD.
This breakdown process is a critical variable to consider when ingesting chemicals. In fact, some pharmaceuticals specifically take this breakdown system into account by creating drugs that inhibit the breakdown of endogenous chemicals so that they can remain effective longer and produce “more” of their intended outcome. For example, SSRIs (Selective Serotonin Reuptake Inhibitors; the leading anti-depressant) delay the breakdown of serotonin (a positive mood-regulating neurotransmitter) in the synapse (the small space that allows transmission of neurotransmitters across neurons) so that an individual’s serotonin (which is usually not as present in depressed populations) can continue to operate, yielding a “happier” person. Similarly, the sluggish breakdown of THC will result in a user feeling “higher” for longer. Unfortunately, this also creates drowsiness in users with the variant for up to three days after initial consumption.
Naturally, insights into which variants on the CYPC9 and CYP2C19 an individual has can help guide dosage and titration models as well identify which product categories to choose. For example, a consumer that is pre-disposed to sub-optimal breakdown would be wise to choose vape products over edible since inhalation bypasses what is known as first-pass metabolism, which occurs in the liver after during digestion of edible. Such information into drug metabolism has fueled the burgeoning field of pharmacogenetics, where medical doctors take a personalized approach to pharmaceutical medication based on the patient’s DNA.
DNA Insights for Personalized Cannabis Use
The effectiveness of cannabis as a treatment option for a wide variety of disorders and diseases, coupled with the reliability of DNA in determining an individual’s likelihood of developing a particular condition, provides an access point for preventative precision cannabis medicine, customized as a function of the consumer’s genetic predispositions.
Taking into account the tens of thousands of cannabis products and strains available on the legal market, there exist a plethora of options with varying cannabinoid and terpene ratios — the most critical variables that determine the different effects and medical benefits of cannabis.
Such a range of products, coupled with an understanding of one’s DNA, allows for a personalized product selection by connecting the dots across different research findings. These biomarkers can create even more precise recommendations that go much further than just warning an individual that they should shy away from edibles.
For example, a host of genes can predispose someone to developing Alzheimer’s and dementia. On the other side of the equation, studies have shown that pinene (a terpene found in cannabis and other plants like pine trees) has a neuroprotective effect that specifically enhances memory. Cannabis users with such predispositions wanting to take preventative health measures could do so by routinely choosing cannabis products high in pinene.
Similar associations exist for users with a tendency to develop schizophrenia or have psychotic episodes, where low-THC, high-CBD products can provide anti-psychotic effects. Similar reasoning applies to individuals at a high-risk for cancer being able to take advantage of high-THC, anti-cancer products.
Cannabis DNA tests like Strain Genie look at over 150 such biomarkers to generate personalized cannabis consumption suggestions.
As regulation allows for scientists to gain access to cannabis for research studies, more insights that can help predetermine the effectiveness of cannabis use at the level of an individual is certainly on the horizon. Other avenues could also provide insights as to other aspects of cannabis use as well. For example, new research from 2018 has even unveiled 35 genes that make you 11% more likely to be a cannabis consumer and revealed an interesting overlap in cannabis use with a gene (CADM2) that has been traditionally associated with risk-taking. Information such as this, combined with genes that predispose individuals for abuse could be used to guide scheduled tolerance breaks.
Regardless of the application, additional research into DNA, cannabinoids, and terpenes promises to refine the personalized approach to cannabis that all consumers should consider taking.
Cannabis Classification System Announced for 2022 Emerald Cup Awards
One of the factors that make the Emerald Cup so important to California’s cannabis market is its continued strive for excellence and innovation. For the 2022 awards, the judging process is undergoing a transformation and with it comes a new cannabis classification system that will classify entries based on terpenes, flavour, and effects for anybody — from customers to budtenders, dispensaries, judges, and cultivators.
Cannabis Is More Than Just THC
The days of just searching out the highest THC totals are rapidly receding as research has now proven that terpenes are at the base of the entourage effect that customers desire are rapidly fading.
Terpenes, on the other hand, have mostly added to the consumer confusion already caused by overly broad Indica/Sativa/Hybrid terminology, whimsical strain names, irrelevant THC/CBD percentages, and other ambiguous factors that make selecting the best or correct strain a less-than-satisfying ordeal for even the most experienced cannabis connoisseurs.
The Emerald Cup competition will serve as a testbed for a new classification system for cannabis flowers. The event organisers and their testing partners at SC Labs decided to further break down the flower categories based on the chemometrics of each cultivar (better known as “chemovar” — the evolution of the term “dominant terpene”) evolving beyond last year’s flower category sorting by primary terpene content, in order to level the playing field and eliminate as much bias as possible in the blind/anonymous sampling done by Emerald Cup judges each year.
This paradigm-shifting insight sparked months of additional research and discussion, culminating in the Emerald Cup Cannabis Classification System based on PhytoFacts® powered by SC Labs.
The all-new classification system builds on last year’s approach of sorting flower entries by primary terpene content, leveraging a decade of Cannabis phytochemistry research between PhytoFacts®, developed by Napro Research in 2013, and a powerful database of over 250,000 terpene tests aggregated by SC Labs, dating back to their launch of terpene testing on Cannabis in 2013. The key class names were chosen to represent current terminology, are widely used in the business and are familiar to dispensaries and consumers. Each class is further explained using taste notes, effects, and popular strains or cultivars to promote understanding and acceptance.
The New Cannabis Classification System
The classes of the Emerald Cup Cannabis Classification Based on PhytoFacts® powered by SC Labs include:
“Jacks + Haze” Class
- Mostly ‘Sativa’-leaning varietals
- Tasting notes – Fruity, Pinesol, Haze
- Effects – Energizing, Cerebral, Artistically Inspiring
- Common Cultivars – Classic Trainwreck, Jack Herer, Durban Poison, Super Lemon Haze
- Terpenes Profile: Terpinolene, Caryophyllene, Myrcene
“Tropical + Floral” Class
- Mostly ‘Indica’-leaning varietals
- Tasting notes – Sweet, Floral, Tropical Fruit
- Effects – Calming, Soothing, Relaxing
- Common Cultivars – Super Skunk, Hawaiian, In the Pines, Dream Queen
- Terpenes Profile: Ocimene, Myrcene
“Sweets + Dreams” Class
- Mostly ‘Indica’-leaning varietals
- Tasting Notes – Fruity, Sweet, Woody, Hoppy, Herbaceous
- Effects – Relaxation, Couch Lock, Analgesic
- Common Cultivars – Blue Dream, Tangie, Forbidden fruit, Grandaddy Purple, Purple Urkel, Grape Ape, Cherry AK, God’s Gift, Purple Punch
- Terpenes Profile: Myrcene, Pinene, Caryophyllene
“OGs + Gas” Class
- True ‘Hybrid’ varietals
- Tasting Notes – Gas, Fuel, Sweet, Citrus, and Pepper
- Effect – Uplifting, Stimulating, Analgesic, Relaxation
- Common Cultivars – Classic OG Kush, ChemDawg, Sour Diesel, Gorilla Glue
- Terpenes Profile: Any combination or shifting codominance of Caryophyllene, Limonene, Myrcene
- True ‘Hybrid’ varietals
- Tasting Notes – Deserts, Doughs, Citrusy & Spicy
- Effects – Stimulating, Racy, Uplifting, Comforting
- Common Cultivars – Classic Bubba Kush, GSC, Gelatos, Cakes
- Any shift in codominance of Caryophyllene & Limonene
“Exotics” (Rare Terpene Combinations) Class
- True ‘Hybrid’ varietals
- Tasting notes – varied based on chemistry of entry
- Effect – varied based on chemistry of entry
- Common Cultivars – rarest terpene profiles entered into the Emerald Cup Competition
This game-changing development in cannabis classification levels the playing ground for the 2022 Cup as well as market competitiveness amongst brands. The system seeks to become an open-source, globally recognised grading solution for Cannabis, with six simple classes/names/descriptions. In the same way that a Chardonnay would not be tested against a Merlot in the wine business, this new system permits strains with comparable profiles to be judged against each other. This new classification system will also be used at the California State Fair Cannabis Awards in July 2022.
The 2022 Emerald Cup Awards will be presented live on stage on May 14th at the Green Street Festival in Downtown Los Angeles, California.
The Sativa Preservation Society Project Will Protect Rare Haze Genetics
Space Coyote, the totally cosmic cannabis company, has launched the Sativa Preservation Society Project — a movement that protects Haze genetics while paying homage to the custodians and cultivators who kept the seeds alive.
Celebrators of the cannabis culture’s stoner heritage, Space Coyote’s aesthetic and ethos embraces the vibes and psychedelic Seventies scene, where the creativity and community of cannabis intersect.
Co-founder and self-confessed ‘Sativa Diva’ Libby Cooper calls it the “ultimate passion project”.
“We’re truly passionate about saving these genetics that are the actual grandmothers of every modern-day sativa strains that people love — all of these desert strains, all of the fruity strains,” Cooper tells me from the Space Coyote van en route to Hall of Flowers.
Founding the Sativa Preservation Society Project
The concept of the Sativa Preservation Society Project was years in incubation as the Space Coyote team deliberated over how to bring it to life. It was important for them to give back to the community while helping to educate about the history of cannabis culture.
The stars aligned earlier this year when the team met Bam Vachher-Gnanathurai, nursery and plant breeding manager from the Posibl Project in Salina. A mutual love of the unique effects of Haze genetics made for a truly cosmic outcome.
“Bam is super passionate about sativa,” said Cooper. “When we went and met up with Bam for the very first time, he rolled a blunt from Cuban Black. It was such an amazing experience to smoke that flower.”
“The initial conversation of the Sativa Preservation Society coming to life happened during that smoke session. It was like, ‘holy shit, we could actually do this.’”
The Haze Experience
The Sativa Preservation Society Project is launching with three incredibly rare cultivars — Cuban Black Haze, Uptown Haze (also known as A5 Haze), and C5 Haze — all of which were originally cultivated in the 1980s by legendary grower Neville Schoenmaker. The flower will be available as bagged eighths and as infused prerolls.
Cooper likens the Haze experience to being “a bit like mushrooms” — colors are brighter, your smell is enhanced and your hearing is sharper.
“It’s really like a cup of coffee without any jitteriness or anxiety usually associated with sativas. This is pure energy without any sort of adverse effects,” explains Cooper. “You really feel as if your eyelids are getting peeled back — you’re awake, you’re uplifted. Basically, I smoke it and I immediately start stretching.”
“Many sativa genetics are dying out due to a number of reasons,” says Cooper. “Typically, they are more difficult to grow, have a longer curing time, and the fluffy buds are easily crushed in transit.” All of which makes sativas less cost-effective in California’s highly competitive legal market.
“This truly is the first time these original sativa strains are going to be commercially grown,” says Cooper. “It really wouldn’t have been possible, funnily enough, without this group named Posibl.”
Learn more about the Sativa Preservation Society Project in the video above. While you’re at it, find your nearest Space Coyote here.
Peach Oz: This Sweet And Juicy Cultivar Will Stimulate Your Creativity
If you’re looking for a premium cultivar with legendary genetics and a euphoric high, look no further than Peach Oz, the latest addition to Wonderbrett’s stellar strain menu.
A cross of Peach Rings with OZ Kush and a descendent of Zkittlez, the sweet, stimulating citrus taste profile of Peach Oz will get your creative juices flowing.
While the cultivar may be new to the public, according to Wonderbrett Co-Founder and famed Breeder Brett Feldman, it’s five-years-old in the world of genetics.
“There’s only a small handful of heady smokers who follow these things,” says Feldman. “I wanted to bring it to the masses to share the experience with everybody. That’s where my passion comes from with this strain. Similar to an amazing dish at a restaurant, you want to share it with your friends.”
Grown in small-batches at scale from the company’s state-of-the-art Long Beach cultivation facility, the strain was first created by Dying Breed Seeds, then perfected by Cannabis By Corey, before making its way to Feldman.
Bursting with flavors and aromas that bring to mind the sweet ocean breeze and fragrant fruit orchards of the California sunshine state, Peach OZ’s four dominant terpenes: Caryophyllene, Linalool, Limonene and Humulene, create a distinct sweet taste of ripe peaches, citrus candy and cream.
“When any strain has that unique, recognizable consistency in its flavor, whether that be peach, lemon or orange, that’s what myself and other breeders appreciate most and look for when bringing a genetic like this to market. It’s mind-blowing what Peach OZ can do that, translating a fruit flavor to a smoking experience,” explained Feldman.
Peach OZ is available at select dispensary and at Wonderbrett’s flagship dispensary in L.A.