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Cannabis DNA Tests Can Tell You How Your Body Responds to Weed

Cannabis DNA tests provide an access point for preventative precision cannabis medicine, customized as a function of the consumer’s genetic predispositions.

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Cannabis DNA Tests
PHOTO | Adobe Stock
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There is a high probability that the following scene has played out at least once in your life: after passing a joint around a smoke circle, one person can’t stop laughing at the painting they insist is moving, another is proclaiming the profundities of Kenrick Lamar’s lyricism, and yet another is “resting their eyes”. While humorous to observe the panoply of personalities, this setting provides an important observation. The cannabinoids and terpenes found in different cannabis products interact with everyone’s internal biochemistry differently.

Naturally, aspects of your lifestyle like how much exercise you’ve been getting, your sleep patterns, and diet all play a role in how you’ll respond to a cannabis product on any given day. However, the most critical factor is the makeup of your endocannabinoid system — the chemicals and neurons in your brain and body that respond to cannabinoids. Your DNA holds the specific instructions for how your endocannabinoid system gets “wired up” compared to other people, permitting for individual differences in reactions to cannabis.

A Quick Introduction to DNA

DNA (deoxyribonucleic acid) is a long molecule that contains the instructions for building every single part of an organism. DNA is made up of four compounds that pair up: (A) Adenine, (T) Thymine, (C) Cytosine, and (G) Guanine. 99.5% of the base pair combinations that make up humans are identical from person to person. The .5% difference is what makes you unique. Variants are the genetic differences that make up that .5%.

You may be familiar with the term “gene”, which is simply a section of DNA that carries the codes for making and organizing specific molecules that eventually serve as the building blocks for different parts and functions of an organism. Variants at specific genes have been identified as the determinants for thousands of different traits, from whether you’ll have blue or green eyes to whether or not you’ll have muscular dystrophy. As new research is conducted on cannabis and the body, more genetic links that can predict your response to cannabis are beginning to surface.

How Your DNA Affects Your Cannabis Consumption

PHOTO | Strain Genie

With genes holding the instructions for the creation of enzymes and proteins that go on to make up all the constituents of your brain and body, it is a small leap of understanding to see how variants at specific genes can affect your endocannabinoid system and, subsequently, your experience with cannabis.

An extreme example of this is Clinical Endocannabinoid Deficiency (CECD) — a genetic condition where the carrier’s body produces significantly less endogenous cannabinoids and receptors as compared to a healthy person. CECD presents an obvious linkage between DNA and cannabis use: if you carry a gene for CECD, you will require substantially more cannabis in order to achieve the same effects as someone without that gene. Other genetic links that predict your response to cannabis can be a bit more insidious.

Take the genes CYP2C9 and CYP2C19 for example; they code for an enzyme that breaks down THC and CDD respectively. Variants on these genes can make the enzymes they create up to 30% less effective. This means that consumers with those variants would be less effective in breaking down THC and CBD.

This breakdown process is a critical variable to consider when ingesting chemicals. In fact, some pharmaceuticals specifically take this breakdown system into account by creating drugs that inhibit the breakdown of endogenous chemicals so that they can remain effective longer and produce “more” of their intended outcome. For example, SSRIs (Selective Serotonin Reuptake Inhibitors; the leading anti-depressant) delay the breakdown of serotonin (a positive mood-regulating neurotransmitter) in the synapse (the small space that allows transmission of neurotransmitters across neurons) so that an individual’s serotonin (which is usually not as present in depressed populations) can continue to operate, yielding a “happier” person. Similarly, the sluggish breakdown of THC will result in a user feeling “higher” for longer. Unfortunately, this also creates drowsiness in users with the variant for up to three days after initial consumption.

Naturally, insights into which variants on the CYPC9 and CYP2C19 an individual has can help guide dosage and titration models as well identify which product categories to choose. For example, a consumer that is pre-disposed to sub-optimal breakdown would be wise to choose vape products over edible since inhalation bypasses what is known as first-pass metabolism, which occurs in the liver after during digestion of edible. Such information into drug metabolism has fueled the burgeoning field of pharmacogenetics, where medical doctors take a personalized approach to pharmaceutical medication based on the patient’s DNA.

DNA Insights for Personalized Cannabis Use

PHOTO | Strain Genie

The effectiveness of cannabis as a treatment option for a wide variety of disorders and diseases, coupled with the reliability of DNA in determining an individual’s likelihood of developing a particular condition, provides an access point for preventative precision cannabis medicine, customized as a function of the consumer’s genetic predispositions.

Taking into account the tens of thousands of cannabis products and strains available on the legal market, there exist a plethora of options with varying cannabinoid and terpene ratios — the most critical variables that determine the different effects and medical benefits of cannabis.

Such a range of products, coupled with an understanding of one’s DNA, allows for a personalized product selection by connecting the dots across different research findings. These biomarkers can create even more precise recommendations that go much further than just warning an individual that they should shy away from edibles.

For example, a host of genes can predispose someone to developing Alzheimer’s and dementia. On the other side of the equation, studies have shown that pinene (a terpene found in cannabis and other plants like pine trees) has a neuroprotective effect that specifically enhances memory. Cannabis users with such predispositions wanting to take preventative health measures could do so by routinely choosing cannabis products high in pinene.

Similar associations exist for users with a tendency to develop schizophrenia or have psychotic episodes, where low-THC, high-CBD products can provide anti-psychotic effects. Similar reasoning applies to individuals at a high-risk for cancer being able to take advantage of high-THC, anti-cancer products.

Cannabis DNA tests like Strain Genie look at over 150 such biomarkers to generate personalized cannabis consumption suggestions.

As regulation allows for scientists to gain access to cannabis for research studies, more insights that can help predetermine the effectiveness of cannabis use at the level of an individual is certainly on the horizon. Other avenues could also provide insights as to other aspects of cannabis use as well. For example, new research from 2018 has even unveiled 35 genes that make you 11% more likely to be a cannabis consumer and revealed an interesting overlap in cannabis use with a gene (CADM2) that has been traditionally associated with risk-taking. Information such as this, combined with genes that predispose individuals for abuse could be used to guide scheduled tolerance breaks.

Regardless of the application, additional research into DNA, cannabinoids, and terpenes promises to refine the personalized approach to cannabis that all consumers should consider taking.

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Cannabis

The Sativa Preservation Society Project Will Protect Rare Haze Genetics

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Sativa Preservation Society Project
PHOTO | SATIVA PRESERVATION SOCIETY PROJECT

Space Coyote, the totally cosmic cannabis company, has launched the Sativa Preservation Society Project — a movement that protects Haze genetics while paying homage to the custodians and cultivators who kept the seeds alive.

Celebrators of the cannabis culture’s stoner heritage, Space Coyote’s aesthetic and ethos embraces the vibes and psychedelic Seventies scene, where the creativity and community of cannabis intersect.

Co-founder and self-confessed ‘Sativa Diva’ Libby Cooper calls it the “ultimate passion project”. 

“We’re truly passionate about saving these genetics that are the actual grandmothers of every modern-day sativa strains that people love — all of these desert strains, all of the fruity strains,” Cooper tells me from the Space Coyote van en route to Hall of Flowers.

Founding the Sativa Preservation Society Project

The concept of the Sativa Preservation Society Project was years in incubation as the Space Coyote team deliberated over how to bring it to life. It was important for them to give back to the community while helping to educate about the history of cannabis culture.

The stars aligned earlier this year when the team met Bam Vachher-Gnanathurai, nursery and plant breeding manager from the Posibl Project in Salina. A mutual love of the unique effects of Haze genetics made for a truly cosmic outcome.

“Bam is super passionate about sativa,” said Cooper. “When we went and met up with Bam for the very first time, he rolled a blunt from Cuban Black. It was such an amazing experience to smoke that flower.” 

“The initial conversation of the Sativa Preservation Society coming to life happened during that smoke session. It was like, ‘holy shit, we could actually do this.’”

The Haze Experience

The Sativa Preservation Society Project is launching with three incredibly rare cultivars — Cuban Black Haze, Uptown Haze (also known as A5 Haze), and C5 Haze — all of which were originally cultivated in the 1980s by legendary grower Neville Schoenmaker. The flower will be available as bagged eighths and as infused prerolls.

Cooper likens the Haze experience to being “a bit like mushrooms” — colors are brighter, your smell is enhanced and your hearing is sharper.

“It’s really like a cup of coffee without any jitteriness or anxiety usually associated with sativas. This is pure energy without any sort of adverse effects,” explains Cooper. “You really feel as if your eyelids are getting peeled back — you’re awake, you’re uplifted. Basically, I smoke it and I immediately start stretching.”

“Many sativa genetics are dying out due to a number of reasons,” says Cooper. “Typically, they are more difficult to grow, have a longer curing time, and the fluffy buds are easily crushed in transit.” All of which makes sativas less cost-effective in California’s highly competitive legal market.

“This truly is the first time these original sativa strains are going to be commercially grown,” says Cooper. “It really wouldn’t have been possible, funnily enough, without this group named Posibl.”

Learn more about the Sativa Preservation Society Project in the video above. While you’re at it, find your nearest Space Coyote here.

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Cannabis

Peach Oz: This Sweet And Juicy Cultivar Will Stimulate Your Creativity

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PEACH FUZZ | PHOTO: WONDERBRETT

If you’re looking for a premium cultivar with legendary genetics and a euphoric high, look no further than Peach Oz, the latest addition to Wonderbrett’s stellar strain menu.

A cross of Peach Rings with OZ Kush and a descendent of Zkittlez, the sweet, stimulating citrus taste profile of Peach Oz will get your creative juices flowing.

While the cultivar may be new to the public, according to Wonderbrett Co-Founder and famed Breeder Brett Feldman, it’s five-years-old in the world of genetics.

“There’s only a small handful of heady smokers who follow these things,” says Feldman. “I wanted to bring it to the masses to share the experience with everybody. That’s where my passion comes from with this strain. Similar to an amazing dish at a restaurant, you want to share it with your friends.”

Grown in small-batches at scale from the company’s state-of-the-art Long Beach cultivation facility, the strain was first created by Dying Breed Seeds, then perfected by Cannabis By Corey, before making its way to Feldman.

Wonderbrett’s grow room | PHOTO: Courtesy Wonderbrett

Bursting with flavors and aromas that bring to mind the sweet ocean breeze and fragrant fruit orchards of the California sunshine state, Peach OZ’s four dominant terpenes: Caryophyllene, Linalool, Limonene and Humulene, create a distinct sweet taste of ripe peaches, citrus candy and cream.  

“When any strain has that unique, recognizable consistency in its flavor, whether that be peach, lemon or orange, that’s what myself and other breeders appreciate most and look for when bringing a genetic like this to market. It’s mind-blowing what Peach OZ can do that, translating a fruit flavor to a smoking experience,” explained Feldman.

Peach OZ is available at select dispensary and at Wonderbrett’s flagship dispensary in L.A.

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Cannabis

Pink Lemonade: This Sparkling Strain Is Both Pretty & Potent

The frosted pink buds of Pink Lemonade might dazzle the beholder with glittering layer of golden trichomes, but this gorgeous flower isn’t all looks.

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Pink Lemonade
PHOTO | Anna Wilcox

Dusted with a glittering layer of golden trichomes, the Pink Lemonade strain is endowed with a mystical appearance that embodies everything curious, attractive, and intriguing about cannabis flowers. Tightly bound calyxes dazzle with a bouquet of pink, violet, and sage coloration.

Cracking open one of these flowers emits a comfortable herbal aroma. A burst of crispness teases the nose, somewhat akin to the tart fizz in a carbonated cherry drink. This dessert-like aroma nicely compliments a definite happy hour high. Calm, relaxed, and downright chill, Pink Lemonade is a true afternoon delight.

The Pink Lemonade High

Put on some chill beats and pour yourself a nice drink. This plant is smooth, easy, and well-rounded. If inhaling Pink Lemonade feels like the first meaningful breath you’ve taken all day, you might be pleasantly surprised as a subtle relaxation works its way along the limbs and through the muscles.

There’s no doubt about it–this plant is a go-to strain for mellowing out. While often described as thoughtful and creative, the herb is better suited to leisure activities than it is serious concentration.

While solo consumers may enjoy putting on some Netflix after a little of this plant, it’s peaceful and contented nature is ideal for social gatherings. Spending time with friends may always be fun, but it’s easy to sit back enjoy a pleasant conversation after a few tastes of Pink Lemonade.

It’s worth mentioning, however, that cannabis affects everyone differently. The herb tends to be a mood enhancer rather than an instant remedy for happiness. If you are in an easygoing and relaxed environment, expect even more mellow after enjoying a little bud. If you’ve been having a bad day, strains like Pink Lemonade may provide relief by softening negative emotions and making them more tolerable.

Pink Lemonade Strain Background

Today’s cannabis market is truly a craft one. To say that the lack of federal recognition of the herb is problematic is an understatement. However, one benefit of state-by-state legalization is the development of truly local, expertly crafted products.

Pink Lemonade is a superb example of such a flower. There are many renditions of Pink Lemonade out there, yet the particular version pictured is a cross between two contemporary hybrids, Lemon Cheesecake and Huckleberry Soda.

Each parent strain is exceptional in its own right. Lemon Cheesecake is a sativa-dominant flower with a sour cream aroma and substantial THC production. Huckleberry Soda is a craft hybrid from Annunkanki Genetics, an intriguing cross between two hybrids, Black Cherry Soda and Huckleberry Hound.

Pink Lemonade Strain Benefits

As a craft flower, Pink Lemonade was arguably bred more for enjoyment than serious medical potential. It’s frosted pink buds dazzle the beholder, showcasing the fact that this plant is truly a treat. However, this gorgeous flower isn’t all looks.

The flower produces upwards of 25 percent THC. This means that the plant may be useful to those who benefit from high-THC therapies. Those interested in making a full-extract oil, hash, or other forms of concentrates may also enjoy experimenting with this sugary herb.

This plant is not too energizing nor is it overly sedative. However, those hoping for a little extra help falling asleep at night may find the flower helpful. The relaxed flower may also be beneficial for anxious individuals in search of a social lubricant.

However, the high-THC content in Pink Lemonade can inspire the opposite effect in some people. Bottom line: if you are prone to social anxiety or often respond poorly to THC, this potent flower is likely not the best choice.

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