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Terpinolene: The Powerful Medicinal Terpene with Anti-Cancer Promise

Terpinolene (sometimes denoted as “TPO”) is considered a minor, or secondary, terpene and features an aroma resembling sweet pine.

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Terpinolene
PHOTO | Pexels
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Few cannabis consumers are fully aware of the complex molecular chemistry of the herb they vaporize, smoke, or eat. Terpenes like terpinolene are the aromatic molecules responsible for the sometimes revealingly pungent aroma of many strains of cannabis. Although the chief purpose of this family of chemicals is an evolutionary defense mechanism against pests and predators, terpenes have been found to deliver medicinal efficacy that equals that of cannabinoids such as CBD and THC.

More than 20,000 terpenes exist throughout nature, about 200 of which have been identified in various strains of cannabis. Terpinolene (sometimes denoted as “TPO”) is considered a minor, or secondary, terpene and features an aroma resembling sweet pine.  It delivers a taste reminiscent of citrus and is produced in many plants in nature other than cannabis, including allspice, cumin, junipers, parsnip, rosemary, sage, and tea tree.

The Details of Terpinolene

In terms of medicinal efficacy, terpinolene kills cancer cells and acts as a sedative. In addition, it displays antibacterial properties and is both an anti-fungal and an anti-oxidant. It is employed as a flavoring agent by various segments of the food industry. It is also used to manufacture plastics and resins and is an effective repellent against pests such as mosquitoes and weevils.

A 2013 study found this special molecule to be a powerful anti-cancer agent. Concluded the study’s researchers, “Our findings clearly demonstrate that terpinolene is a potent antiproliferative agent for brain tumour cells and may have potential as an anticancer agent, which needs to be further studied.”

The Research

A 2013 study entitled “Anticancer and Antioxidant Properties of Terpinolene” that was published in the journal Arh Hig Rada Toksikol found terpinolene to be a “potent antiproliferative agent for brain tumour cells” and surmised that this powerfully medicinal terpene “may have potential as an anticancer agent,” an issue in obvious need of further research due to the 91 million people worldwide who suffer more than 100 types of cancers.

The researchers concluded, “Our findings clearly demonstrate that terpinolene is a potent antiproliferative agent for brain tumor cells and may have potential as an anticancer agent, which needs to be further studied.”

A 2012 study entitled “Terpinolene, a Component of Herbal Sage, Downregulates AKT1 Expression in K562 Cells” and published in the journal Oncology Letters found the terpene terpinolene to be an effective agent in the battle against a variety of cancers.

Concluded the study’s researchers, “Increased expression and/or activation of AKT is involved in a variety of human cancers. In cells treated with sage or rosemary extract, mRNA and protein expression levels of AKT1 were reduced compared with those of the control cells 48 hours after the herbal treatments. We found that terpinolene, a common component of sage and rosemary, markedly reduced the protein expression of AKT1 in K562 cells and inhibited cell proliferation.”

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Cannabis

The Sativa Preservation Society Project Will Protect Rare Haze Genetics

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Sativa Preservation Society Project
PHOTO | SATIVA PRESERVATION SOCIETY PROJECT

Space Coyote, the totally cosmic cannabis company, has launched the Sativa Preservation Society Project — a movement that protects Haze genetics while paying homage to the custodians and cultivators who kept the seeds alive.

Celebrators of the cannabis culture’s stoner heritage, Space Coyote’s aesthetic and ethos embraces the vibes and psychedelic Seventies scene, where the creativity and community of cannabis intersect.

Co-founder and self-confessed ‘Sativa Diva’ Libby Cooper calls it the “ultimate passion project”. 

“We’re truly passionate about saving these genetics that are the actual grandmothers of every modern-day sativa strains that people love — all of these desert strains, all of the fruity strains,” Cooper tells me from the Space Coyote van en route to Hall of Flowers.

Founding the Sativa Preservation Society Project

The concept of the Sativa Preservation Society Project was years in incubation as the Space Coyote team deliberated over how to bring it to life. It was important for them to give back to the community while helping to educate about the history of cannabis culture.

The stars aligned earlier this year when the team met Bam Vachher-Gnanathurai, nursery and plant breeding manager from the Posibl Project in Salina. A mutual love of the unique effects of Haze genetics made for a truly cosmic outcome.

“Bam is super passionate about sativa,” said Cooper. “When we went and met up with Bam for the very first time, he rolled a blunt from Cuban Black. It was such an amazing experience to smoke that flower.” 

“The initial conversation of the Sativa Preservation Society coming to life happened during that smoke session. It was like, ‘holy shit, we could actually do this.’”

The Haze Experience

The Sativa Preservation Society Project is launching with three incredibly rare cultivars — Cuban Black Haze, Uptown Haze (also known as A5 Haze), and C5 Haze — all of which were originally cultivated in the 1980s by legendary grower Neville Schoenmaker. The flower will be available as bagged eighths and as infused prerolls.

Cooper likens the Haze experience to being “a bit like mushrooms” — colors are brighter, your smell is enhanced and your hearing is sharper.

“It’s really like a cup of coffee without any jitteriness or anxiety usually associated with sativas. This is pure energy without any sort of adverse effects,” explains Cooper. “You really feel as if your eyelids are getting peeled back — you’re awake, you’re uplifted. Basically, I smoke it and I immediately start stretching.”

“Many sativa genetics are dying out due to a number of reasons,” says Cooper. “Typically, they are more difficult to grow, have a longer curing time, and the fluffy buds are easily crushed in transit.” All of which makes sativas less cost-effective in California’s highly competitive legal market.

“This truly is the first time these original sativa strains are going to be commercially grown,” says Cooper. “It really wouldn’t have been possible, funnily enough, without this group named Posibl.”

Learn more about the Sativa Preservation Society Project in the video above. While you’re at it, find your nearest Space Coyote here.

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Cannabis

Peach Oz: This Sweet And Juicy Cultivar Will Stimulate Your Creativity

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PEACH FUZZ | PHOTO: WONDERBRETT

If you’re looking for a premium cultivar with legendary genetics and a euphoric high, look no further than Peach Oz, the latest addition to Wonderbrett’s stellar strain menu.

A cross of Peach Rings with OZ Kush and a descendent of Zkittlez, the sweet, stimulating citrus taste profile of Peach Oz will get your creative juices flowing.

While the cultivar may be new to the public, according to Wonderbrett Co-Founder and famed Breeder Brett Feldman, it’s five-years-old in the world of genetics.

“There’s only a small handful of heady smokers who follow these things,” says Feldman. “I wanted to bring it to the masses to share the experience with everybody. That’s where my passion comes from with this strain. Similar to an amazing dish at a restaurant, you want to share it with your friends.”

Grown in small-batches at scale from the company’s state-of-the-art Long Beach cultivation facility, the strain was first created by Dying Breed Seeds, then perfected by Cannabis By Corey, before making its way to Feldman.

Wonderbrett’s grow room | PHOTO: Courtesy Wonderbrett

Bursting with flavors and aromas that bring to mind the sweet ocean breeze and fragrant fruit orchards of the California sunshine state, Peach OZ’s four dominant terpenes: Caryophyllene, Linalool, Limonene and Humulene, create a distinct sweet taste of ripe peaches, citrus candy and cream.  

“When any strain has that unique, recognizable consistency in its flavor, whether that be peach, lemon or orange, that’s what myself and other breeders appreciate most and look for when bringing a genetic like this to market. It’s mind-blowing what Peach OZ can do that, translating a fruit flavor to a smoking experience,” explained Feldman.

Peach OZ is available at select dispensary and at Wonderbrett’s flagship dispensary in L.A.

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Cannabis

Pink Lemonade: This Sparkling Strain Is Both Pretty & Potent

The frosted pink buds of Pink Lemonade might dazzle the beholder with glittering layer of golden trichomes, but this gorgeous flower isn’t all looks.

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Pink Lemonade
PHOTO | Anna Wilcox

Dusted with a glittering layer of golden trichomes, the Pink Lemonade strain is endowed with a mystical appearance that embodies everything curious, attractive, and intriguing about cannabis flowers. Tightly bound calyxes dazzle with a bouquet of pink, violet, and sage coloration.

Cracking open one of these flowers emits a comfortable herbal aroma. A burst of crispness teases the nose, somewhat akin to the tart fizz in a carbonated cherry drink. This dessert-like aroma nicely compliments a definite happy hour high. Calm, relaxed, and downright chill, Pink Lemonade is a true afternoon delight.

The Pink Lemonade High

Put on some chill beats and pour yourself a nice drink. This plant is smooth, easy, and well-rounded. If inhaling Pink Lemonade feels like the first meaningful breath you’ve taken all day, you might be pleasantly surprised as a subtle relaxation works its way along the limbs and through the muscles.

There’s no doubt about it–this plant is a go-to strain for mellowing out. While often described as thoughtful and creative, the herb is better suited to leisure activities than it is serious concentration.

While solo consumers may enjoy putting on some Netflix after a little of this plant, it’s peaceful and contented nature is ideal for social gatherings. Spending time with friends may always be fun, but it’s easy to sit back enjoy a pleasant conversation after a few tastes of Pink Lemonade.

It’s worth mentioning, however, that cannabis affects everyone differently. The herb tends to be a mood enhancer rather than an instant remedy for happiness. If you are in an easygoing and relaxed environment, expect even more mellow after enjoying a little bud. If you’ve been having a bad day, strains like Pink Lemonade may provide relief by softening negative emotions and making them more tolerable.

Pink Lemonade Strain Background

Today’s cannabis market is truly a craft one. To say that the lack of federal recognition of the herb is problematic is an understatement. However, one benefit of state-by-state legalization is the development of truly local, expertly crafted products.

Pink Lemonade is a superb example of such a flower. There are many renditions of Pink Lemonade out there, yet the particular version pictured is a cross between two contemporary hybrids, Lemon Cheesecake and Huckleberry Soda.

Each parent strain is exceptional in its own right. Lemon Cheesecake is a sativa-dominant flower with a sour cream aroma and substantial THC production. Huckleberry Soda is a craft hybrid from Annunkanki Genetics, an intriguing cross between two hybrids, Black Cherry Soda and Huckleberry Hound.

Pink Lemonade Strain Benefits

As a craft flower, Pink Lemonade was arguably bred more for enjoyment than serious medical potential. It’s frosted pink buds dazzle the beholder, showcasing the fact that this plant is truly a treat. However, this gorgeous flower isn’t all looks.

The flower produces upwards of 25 percent THC. This means that the plant may be useful to those who benefit from high-THC therapies. Those interested in making a full-extract oil, hash, or other forms of concentrates may also enjoy experimenting with this sugary herb.

This plant is not too energizing nor is it overly sedative. However, those hoping for a little extra help falling asleep at night may find the flower helpful. The relaxed flower may also be beneficial for anxious individuals in search of a social lubricant.

However, the high-THC content in Pink Lemonade can inspire the opposite effect in some people. Bottom line: if you are prone to social anxiety or often respond poorly to THC, this potent flower is likely not the best choice.

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