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Is Nano-Cannabinoid Technology the New Frontier of Medicine?

The Honest Marijuana Company is currently working on a nano-cannabinoid technology that will deliver cannabinoids in a time-released fashion.

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nano-cannabinoid technology
PHOTO | Courtesy Honest Marijuana Co.
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One all-natural cannabis growery is changing the face of cannabis-based medicine, one microscopic molecule at a time. This spring, the Honest Marijuana Company (HMC) will introduce one of the industry’s most innovative products yet; nano-cannabinoid technology. The formulations — which will come in capsule, topical and other forms — allow users to feel the effects of cannabinoids in one minute or less.

The patent-pending technology turns non-water-soluble substances like cannabinoids (including THC and CBD) into nano-sized particles that range from 18-24 nanometers, according to the Colorado-based company. Twenty nanometers is roughly a thousand times smaller than the diameter of a human red blood cell. These microscopic cannabinoids can travel quickly through transdermal or other membranes, and directly into the bloodstream.

Nano-Cannabinoid Technology 101

There are many ways to “shrink” particles into nanoparticles. It can be done through sound waves, or by turning a hydrophobic substance into a water-soluble substance through emulsion (mixing or suspending fat/oil in water so it can be dissolved in water).  

Though the overall process of creating nano-cannabinoid technology remains proprietary, it basically boils down to making particles small enough so that they are watersoluble and will transfer through the skin, Anthony Franciosi, HMC’s head grower, explained to Cannabis Aficionado.

In comparison to other forms of consumption, this technology allows for a quicker, cleaner, and more efficient delivery. One obvious reason is that it provides an alternative to smoking and the inherent harm and indiscretion that comes with it.

Nanotechnology in medicine is particularly efficient because it increases the bioavailability of a particular compound — in this case, cannabinoids. Merriam-Webster defines bioavailability as “the degree and rate at which a substance is absorbed into a living system or is made available at the site of physiological activity.” To oversimplify: when a substance passes through the human system, its bioavailability is reduced because, well, our metabolisms.

Unlike eating an infused edible, effects of nano-cannabinoids can be felt immediately (within 45-65 seconds) as the medicine doesn’t need to be digested — just absorbed. The digestion process lessens the efficiency of cannabinoids; skipping that process effectively makes them more active (or, more potent). It also means customers will need less medicine to feel desired effects. In pharmacology, that’s called “skipping the first pass.”

PHOTO: Courtesy Honest Marijuana Co.

According to HMC, by the time THC enters your system and bloodstream after eating an infused edible, it is already not THC. It becomes a THC derivative — a different formula known as 11-Hydroxy-THC. The compound has pain-relieving and sedative values to it, but THC in the purest form is more stimulating and psychoactive. The company’s formulation delivers THC directly into the system without it converting into the 11-Hydroxy-THC. In the pharmaceutical terms, it is called “skipping the first pass.”

The company plans to use the new nano-technology to create a new generation of transdermal patches, creams, and topicals. They have almost completed their formulation for a dissolvable oral strip, Nanobidiol™.

The new technology is yet another successful attempt by HMC. to create clean products. Their growery is renowned for cultivating some of the purest cannabis around. They are also known for introducing organic hemp-wrapped blunts, and the first-of-its-kind tin can packaging for cannabis.

Their world-class growing methods use “living soil with plant-based nutrients, organic teas and probiotics to bring out the fullest genetic expression of every strain,” said the company’s head grower, Anthony Franciosi.

“We use highly efficient environmental controls and lighting in conjunction with organic inputs to try to create the cleanest marijuana we can,” Franciosi explained. “We collect a good portion of the water we use through collection tanks attached to our environmental controls and reuse it continuously.”

Organic soil-grown cannabis tends to have a wider cannabinoid and terpene profile, Franciosi added, “and in my opinion has a much better taste.” The fact that you can consume it knowing precautions were taken to protect the environment, and that no harmful chemicals were added, add to the experience as well, he explained.

Discretion and efficiently are also key to that experience as well; the role of technology is to boost those benefits. In the growery, this means using innovative lighting, climate control, and sustainable water collection systems to produce pure, sustainable products. Outside of the greenhouse, that means creating cleaner ways to consume cannabis.

HMC “use highly efficient LEC lighting, which ensures a 30 percent lower power draw on the community’s resources.” Furthermore, the facility’s chilled climate control system “uses 30 percent less electricity than a standard HVAC system.

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Peach Oz: This Sweet And Juicy Cultivar Will Stimulate Your Creativity

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PEACH FUZZ | PHOTO: WONDERBRETT

If you’re looking for a premium cultivar with legendary genetics and a euphoric high, look no further than Peach Oz, the latest addition to Wonderbrett’s stellar strain menu.

A cross of Peach Rings with OZ Kush and a descendent of Zkittlez, the sweet, stimulating citrus taste profile of Peach Oz will get your creative juices flowing.

While the cultivar may be new to the public, according to Wonderbrett Co-Founder and famed Breeder Brett Feldman, it’s five-years-old in the world of genetics.

“There’s only a small handful of heady smokers who follow these things,” says Feldman. “I wanted to bring it to the masses to share the experience with everybody. That’s where my passion comes from with this strain. Similar to an amazing dish at a restaurant, you want to share it with your friends.”

Grown in small-batches at scale from the company’s state-of-the-art Long Beach cultivation facility, the strain was first created by Dying Breed Seeds, then perfected by Cannabis By Corey, before making its way to Feldman.

Wonderbrett’s grow room | PHOTO: Courtesy Wonderbrett

Bursting with flavors and aromas that bring to mind the sweet ocean breeze and fragrant fruit orchards of the California sunshine state, Peach OZ’s four dominant terpenes: Caryophyllene, Linalool, Limonene and Humulene, create a distinct sweet taste of ripe peaches, citrus candy and cream.  

“When any strain has that unique, recognizable consistency in its flavor, whether that be peach, lemon or orange, that’s what myself and other breeders appreciate most and look for when bringing a genetic like this to market. It’s mind-blowing what Peach OZ can do that, translating a fruit flavor to a smoking experience,” explained Feldman.

Peach OZ is available at select dispensary and at Wonderbrett’s flagship dispensary in L.A.

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Pink Lemonade: This Sparkling Strain Is Both Pretty & Potent

The frosted pink buds of Pink Lemonade might dazzle the beholder with glittering layer of golden trichomes, but this gorgeous flower isn’t all looks.

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Pink Lemonade
PHOTO | Anna Wilcox

Dusted with a glittering layer of golden trichomes, the Pink Lemonade strain is endowed with a mystical appearance that embodies everything curious, attractive, and intriguing about cannabis flowers. Tightly bound calyxes dazzle with a bouquet of pink, violet, and sage coloration.

Cracking open one of these flowers emits a comfortable herbal aroma. A burst of crispness teases the nose, somewhat akin to the tart fizz in a carbonated cherry drink. This dessert-like aroma nicely compliments a definite happy hour high. Calm, relaxed, and downright chill, Pink Lemonade is a true afternoon delight.

The Pink Lemonade High

Put on some chill beats and pour yourself a nice drink. This plant is smooth, easy, and well-rounded. If inhaling Pink Lemonade feels like the first meaningful breath you’ve taken all day, you might be pleasantly surprised as a subtle relaxation works its way along the limbs and through the muscles.

There’s no doubt about it–this plant is a go-to strain for mellowing out. While often described as thoughtful and creative, the herb is better suited to leisure activities than it is serious concentration.

While solo consumers may enjoy putting on some Netflix after a little of this plant, it’s peaceful and contented nature is ideal for social gatherings. Spending time with friends may always be fun, but it’s easy to sit back enjoy a pleasant conversation after a few tastes of Pink Lemonade.

It’s worth mentioning, however, that cannabis affects everyone differently. The herb tends to be a mood enhancer rather than an instant remedy for happiness. If you are in an easygoing and relaxed environment, expect even more mellow after enjoying a little bud. If you’ve been having a bad day, strains like Pink Lemonade may provide relief by softening negative emotions and making them more tolerable.

Pink Lemonade Strain Background

Today’s cannabis market is truly a craft one. To say that the lack of federal recognition of the herb is problematic is an understatement. However, one benefit of state-by-state legalization is the development of truly local, expertly crafted products.

Pink Lemonade is a superb example of such a flower. There are many renditions of Pink Lemonade out there, yet the particular version pictured is a cross between two contemporary hybrids, Lemon Cheesecake and Huckleberry Soda.

Each parent strain is exceptional in its own right. Lemon Cheesecake is a sativa-dominant flower with a sour cream aroma and substantial THC production. Huckleberry Soda is a craft hybrid from Annunkanki Genetics, an intriguing cross between two hybrids, Black Cherry Soda and Huckleberry Hound.

Pink Lemonade Strain Benefits

As a craft flower, Pink Lemonade was arguably bred more for enjoyment than serious medical potential. It’s frosted pink buds dazzle the beholder, showcasing the fact that this plant is truly a treat. However, this gorgeous flower isn’t all looks.

The flower produces upwards of 25 percent THC. This means that the plant may be useful to those who benefit from high-THC therapies. Those interested in making a full-extract oil, hash, or other forms of concentrates may also enjoy experimenting with this sugary herb.

This plant is not too energizing nor is it overly sedative. However, those hoping for a little extra help falling asleep at night may find the flower helpful. The relaxed flower may also be beneficial for anxious individuals in search of a social lubricant.

However, the high-THC content in Pink Lemonade can inspire the opposite effect in some people. Bottom line: if you are prone to social anxiety or often respond poorly to THC, this potent flower is likely not the best choice.

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Wizard Stones: The Magic of Making Cannabis Diamonds

Aaron Palmer and Graham Jennings, founders of Oleum Extracts in Washington State, talk about Wizard Stones, their THCA isolate product.

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Wizard Stones
PHOTO | Oleum Extracts

Heat, pressure, and time. The three components required to form a diamond from carbon. But what about diamonds made from cannabis? The founders of Oleum Extracts, Aaron Palmer and Graham Jennings both agree that a good cannabis diamond aka Wizard Stones ultimately comes down to the flavor provided by its terpene fraction.

‘Diamonds’ is a slang term for the crystal formations of the cannabinoid THCA. The molecule’s lattice structure builds upon itself naturally as individual molecules clump together creating the faceted formations that resemble diamond or quartz.

When most people talk about cannabis diamonds, they’re talking about THCA structures that form in their own terpene sauce. So, it’s a little different technique than other isolation methods.

While their chemical composition is the same, the process to make them is slightly different than the traditional diamonds mined from a raw extract. Instead, they use a specially formulated solvent mix to create a solution with a composition that encourages crystallization.

Due to Washington state’s regulations, Oleum is limited in the chemical solvents they can use. So that blend is the crucial variable to isolating THCA into their Wizard Stones product.

Growing cannabis diamonds within their original terpene fraction comes down to creating an environment with the right amounts of pressure and heat to encourage crystal growth.

Within the raw extract, the terpene and cannabinoid compounds are homogenized together, but as they settle and separate the mixture “crashes” — which is the start of crystallization.

Palmer explains that this process “helps to create a seed because if there’s nothing for the THCA molecules to grab onto then they have a harder time starting the diamond formation.”

There are a few ways extractors seed a solution to start diamond growth, but Oleum prefers to use freezing temperatures to solidify and then thaw their extract, helping to create small groupings of THCA for other molecules to stack off.

Another common seeding technique is to drop a previously grown crystal into the extracted mixture of cannabis compounds, giving the THCA something to grow off.

This technique is especially useful when filming a time-lapse of the crystal growth because it gives the camera a focal point knowing where the formation will grow from.

Creating Wizard Stones

The above timelapse video was photographed over a four day period by Dankshire. We can see diamonds begin to form almost immediately. However, the crystallization process can take a month if not longer to complete once a raw extract is jarred and waiting to crash.

Oleum utilizes custom-built isolation vessels for their production diamond runs but admits that the jar tech allows more visibility into the process.

Jennings points out, “You see the jars, we even do the jar stuff a lot. It’s more popular… and people know what it is compared to a large isolation vessel that no one can see into it but you know it’s growing 2,000 grams of crystals.”

Each batch can present a different ratio of diamonds to sauce and it seems like everyone wants a little different combination. “We just give ‘em what it makes,” Jennings said.

That’s the beauty of isolated products like cannabis diamonds and sauce; you can mix your own cocktail of cannabis compounds and really dial in the flavors and feelings that you’re after.

Wizard Stones grown in their own sauce create a potent, refined, and pronounce expression of the strain they are extracted from.

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